英國Farfield
英國Farfield公司致力于為全球的生物學蛋白檢測、表面科學及納米科技領域提供創新的科學分析儀器,使用戶在分子甚至原子的層面上理解物質之間的相互作用及作用期間的實時變化,給出相應的動力學及熱力學參數,如:分子直徑、厚度、密度、表面濃度及固-液、液-液界面薄膜實時反應和變化。公司核心的DPI (Dual Polarization Interferometry)技術及基于DPI技術的AnaLight系列雙偏振極化干涉測量分析系統應用范圍包括:
蛋白質科學研究應用:
1、定量測量蛋白質構象變化分析
2、蛋白質聚集、折疊分析(Alzheimer's等神經退行性疾病)
3、蛋白質與小分子(如藥物小分子、金屬離子等)間相互作用
4、膜、脂和蛋白質間相互作用
5、蛋白質和多肽等大分子間相互作過程分析、藥物篩選
6、抗原-抗體;受體-配體
表面分析應用:
1、表活劑、聚合物等界面相互作用研究
2、界面物理化學、界面科學、洗脫研究
3、膠體表面化學中兩親分子有序組合體和分子自組裝研究
4、生物材料表面化學(如隱形眼鏡、體內植入體等)
DPI為定量測量技術,尤其在蛋白質結構及蛋白質與小分子之間的相互作用的研究領域突破目前所有其它即時測量分子動力學技術的瓶頸。該技術在上述領域應用廣泛并發表大量文獻。被稱做”分子顯微鏡“的DPI儀器是目前測量分子相互作用時結構及構象變化最靈敏的技術平臺。由于DPI技術具有極高的靈敏度,能夠測量分子之間相互作用時分子層中<0.1A厚度及<0.1pg/平方毫米密度的實時的變化(如分子量為100000Da的蛋白和分子量為50Da的小分子相互作用,感應靈敏度<5Da),并給出動力學及熱力學變化曲線,因此DPI技術提供的數據與核磁共振(NMR)、X射線晶體衍射(X-ray Crystallograph)及中子反射等相比更具有優越性, 是其他生物傳感技術如SPR、QCM等無法比擬的。
Farfield Scientific Inc. leads the field as an innovator, developer and supplier of analytical instruments designed to address the emerging and evolving molecular-scale measurement demands of scientific discovery. Our tools and solutions meet and exceed the most rigorous measurement challenges faced by scientific research in the United States over the next decade.
Our instruments are advancing the frontiers of molecular research in biophysics, surface science and nanotechnology. Our customers are at the forefront of their research fields. Our products are based on a complete understanding and independent verification of the underlying physics of metrology.
Farfield Instruments provide results in "real time", providing our customers with information that can make immediate impact on their analysis, research and speed of products to market.
The support we provide to our customers, and the progress our customers make, is based on Farfield's active engagement with your scientific community. We share your molecular-scale research aspirations and succeed through your science.
Farfield Scientific Inc. is a member of the Farfield Group of Companies
Location & Contact
We would like to hear from you and to discuss ways we can engage and accelerate your research programs.
Farfield Scientific Inc. headquarters office is located in Pittsburgh, Pennsylvania
Farfield Scientific Inc.
4514 Plummer Street
Pittsburgh, PA 15201