Scarab Genomics
Scarab Genomics公司是由威斯康星大學遺傳學家弗雷德?布拉特納(Fred Blattner)組建的一家私營公司,其主要把科研上常用的細菌大腸桿菌分解。布拉特納希望經他刪減過的“純凈基因組”細菌能在實驗室和工業中顯示出它的安全和高效。并將其市場化
Scarab Genomics was established in 2002. The Clean Genome? E. coli is the result of Dr. Fred Blattner's research at the University of Wisconsin, Madison. Scarab Genomics has licensed the patented reduced genome technology from Wisconsin Alumni Research Foundation on an exclusive, worldwide basis.
Scarab Genomics has bioengineered the Clean Genome? E. coli by deleting over 15% of the genome. Genome reduction optimizes the E. coli as a biological factory. Elimination of recombinogenic or mobile DNA, toxins and virulence genes and non-essential genes provides increased genome and plasmid stability and improved metabolic efficiency. Clean Genome? E. coli is the strain of choice for a wide spectrum of applications ranging from routine cloning to production of biopharmaceuticals.
The Significance of the Scarab
To ancient Egyptians, scarab beetles with their beautiful iridescent carapaces suitable for jewelry were talismans of good luck and represented new life. To Scarab Genomics new life comes when application of synthetic biology leads to improved E. coli strains for research and therapeutic applications.